BIOMARK AND ITS TEAM OF COLLABORATORS SECURE CHRP FUNDING

Vancouver, British Columbia – (April 17, 2019) – BioMark Diagnostics Inc. (“BioMark”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) is pleased to announce that its application entitled “Development and clinical assessment of novel biomarker drugs targeting SSAT1 for detection and therapeutic monitoring of glioblastoma”, submitted to the Collaborative Health Research Projects funding opportunity, has been approved. The application was Canadian Institutes of Health Research (CIHR) in partnership with the Natural Sciences and Engineering Research Council of Canada (NSERC) and in collaboration with the Social Sciences and Humanities Research Council (SSHRC). The funding is approximately for $400,000. BioMark is the industrial partner on the grant.

 

The company would like to thank Drs D. Miller, T. Klonish, T. Lakowski, M. Pitz and D. Wishart who contributed immensely during the application process. Rashid Ahmed, President and CEO, says “It was highly competitive, and we are delighted to be amongst a select group of applicants that secured the funding. This demonstrates the quality of our application based on key measures such as scientific merit, calibre of the team and potential clinical impact. Assembling a high impact multi- disciplinary team to collaborate in developing potentially disruptive diagnostic test that can improve identification and care for patients with glioblastoma is exciting.”

 

BioMark would like to acknowledge CIHR, NSERC and SSHRC for the funding. In addition, the company thanks the numerous reviewers for their excellent feedback.

 

About CHRP

Collaborative Health Research Projects (CHRP) is a joint initiative between the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Social Sciences and Humanities Research Council of Canada (SSHRC). CHRP grants support focused, interdisciplinary, collaborative research projects involving any field of the natural sciences or engineering and any field of the health sciences.

Proposed research projects should be innovative, with a strong focus on knowledge translation, and lead to health benefits for Canadians, more effective health services and/or economic development in health-related areas.

 

About Glioblastoma Multiforme (GBM)

The most common primary brain tumour in adults is glioblastoma (GBM). Originating from transformed neural precursor cells, GBM is a highly aggressive and infiltrative brain tumour.  The death rate of GBM worldwide is approximately 225,000 per year (1).  While GBM has a lower incidence than many other cancers, the prognosis is particularly poor with average survival from time of diagnosis being approximately 14-16 months (2, 3).  Furthermore, compared to other cancers such as breast cancer, which have seen significant advancements in treatment and increased survival, the survival rates for GBM remain similar to those 30 years ago (4).

Monitoring of tumour response is typically through magnetic resonance imaging (MRI) of the brain, typically every 2-3 months. The poor prognosis associated with GBM is a combination of lack of early detection, incomplete surgical resections of tumour mass and ineffective postsurgical treatment options.  Thus, the ability to detect GBM while the patient is still asymptomatic is likely to create a positive ripple effect with improvements in both the surgical resection and radiation and chemotherapeutic outcomes.  Perhaps an even more profound impact of the proposed study is the potential use as a diagnostic drug biomarker to monitor GBM progression during treatment and early detection of tumour re-occurrence. Thus, a reliable and affordable diagnostic agent that could monitor therapeutic response in GBM patients would allow the clinician and patient to move to new therapies more quickly.

 

References:

  1. Alphandery E. (2018). Glioblastoma treatments: An account of recent industrial developments. Front. Pharmacol. 9:879.
  2. Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, and Villano JL. (2014). Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol. Biomarkers Prev. 23:1985-1996.
  3. Carlsson SK, Brothers SP, and Wahlestedt C. (2014). Emergine treatment strategies for glioblastoma mulitforme. EMBO Mol. Med. 6:1359-1370.
  4. Fine HA. (2015). New strategies in glioblastoma: exploiting the new biology. Clin Cancer Res. 21:1984-1988.

Press Release – BIOMARK AND ITS TEAM OF COLLABORATORS SECURE CHRP FUNDING

BIOMARK CLOSES THE PRIVATE PLACEMENT OFFERING

April 16th, 2019 – Vancouver, British Columbia – BioMark Diagnostics Inc. (“BioMark” or the “Company”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) is pleased to announce that further to its press release of April 9th, 2019, it has closed the non-brokered private placement for gross proceeds of $200,000.00 wherein BioMark issued 2,000,000 units at a price of $ 0.10 per unit.

 

Each unit consists of one common share of BioMark and one share purchase warrant. One whole share purchase warrant will entitle the holder thereof to purchase one common share of BioMark at $0.20 per share for a period of two years from the closing date of the private placement, subject to an acceleration clause. No Finders’ fees were payable on the private placement.

 

The proceeds of the private placement will be used for necessary regulatory submission activities, sourcing clinical samples and general working capital. The securities issued under the private placement will be subject to a hold period of four months and one day.

 

Certain Insiders, Directors and Officers subscribed for a portion of this placement. Participation of the insiders of the Company in the private placement constitutes a related party transaction as defined under Multilateral Instrument 61-101 (Protection of Minority Security Holders in Special Transactions). Because the Company’s shares trade only on the CSE, the issuance of securities is exempt from the formal valuation requirements of Section 5.4 of MI 61-101 pursuant to Subsection 5.5(b) of MI 61-101 and exempt from the minority approval requirements of Section 5.6 of MI 61-101. The Company did not file a material change report 21 day prior to the closing of the private placement as the details of the participation of insiders of the Company had not been confirmed at that time.

Press Release – Biomark Closes the Private Placement – April 2019

BIOMARK ANNOUNCES THE PRIVATE PLACEMENT

Vancouver, British Columbia – (April 9th, 2019) – BioMark Diagnostics Inc. (“BioMark”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) is pleased to announce a non-brokered Private Placement (the “Offering”). The Offering will be for up to 2,000,000 Units at a price of $0.10 to raise gross proceeds of up to $200,000.

 

Each Unit is composed of one common share (a “Share”) of the Company and one Share purchase warrant (a “Warrant”). Each whole Warrant shall entitle the holder to acquire one Share at a price of $0.20 per Share for a period of two years after the date of issuance. Finder’s fees may be payable. The private placement and finder’s fees are subject to regulatory approval.

 

The proceeds of the Offering will be used for further regulatory submission activities, product development, sourcing clinical samples and general working capital. The securities in the private placement will be subject to a holding period of four months from the closing date of the private placement. Certain Insiders, Directors and Officers may subscribe for a portion of this placement. Closing of the private placement is subject to the Canadian Securities Exchange approval.

 

Press Release BIOMARK ANNOUNCES PRIVATE PLACMENT April 2019

BIOMARK’S ABSTRACT ACCEPTED FOR 2019 ASCO ONLINE PUBLICATION

Vancouver, British Columbia – (April 3, 2019) – BioMark Diagnostics Inc. (“BioMark”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) is pleased to announce that the abstract submitted to the American Society of Clinical Oncology (ASCO) under Dr. Andrew Maksymiuk was accepted for online publication. The abstract was titled “Follow-up evaluation of outliers with elevated spermine-spermidine acetyltransferase-1 activity”.

 

 

Rashid Ahmed, President and CEO, says, “This is an important milestone for BioMark and we are delighted with the scientific and clinical progress our team has made over the past few months. This year, ASCO received more than 6,200 abstracts, which were reviewed by their Scientific Program Committee and ASCO Leadership.” The 2019 ASCO Annual Meeting will be take place May 31 – June 4, 2019 at the McCormick Place Convention Center in Chicago, Illinois.  The majority of abstracts, including our abstract, will be released by ASCO on May 15, 2019, at 5:00 PM EDT on abstracts.asco.org.

 

About ASCO

Founded in 1964, the American Society of Clinical Oncology is the world’s leading professional organization for physicians and oncology professionals caring for people with cancer. ASCO has over 45,000 members globally. For the 2019 ASCO annual meeting the focus will be on a unique global exchange of information on how to drive progress and expand the reach of quality care for all patients. Learn More about ASCO at https://www.asco.org/about-asco.

Press Release – BioMark’s Abstract Accepted For ASCO 2019 Online Publication