BioMark’s Market Update Report

Vancouver, British Columbia – (February 4th, 2020) – BioMark Diagnostics Inc. (“BioMark”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) is pleased to provide a market update report with key activities undertaken by BioMark’s team during January 2020.


“BioMark is not aware of any negative news that has impacted its share price recently. We continue to execute well as discussed in our 2019 Round Up and Outlook for 2020 yearend report. I would like to share with you some key activities undertaken by BioMark’s team during January 2020 that demonstrates our commitment to achieve our goals in 2020 says”, Rashid Ahmed CEO and President of BioMark.


  • BioMark team attended MEDTEQ Innovation Summit on January 13 -16, 2020 in Montreal, met with MEDTEQ team and discussed funding application status which is currently being reviewed by the Government of Quebec economic team. The funding is for over $650,000.
  • BioMark team met with Canada Brain Foundation to explore potential grants and funding for brain related projects across Canada. This is timely given our breakthrough research being conducted in Glioblastoma (aggressive brain cancer) and is being led by Dr. Don Miller and his team.
  • BioMark team presented at IUCPQ in Quebec City and managed to review and discussed the large prospective study plan with Dr. Joubert and the IUCPQ biobank team. We anticipate to source samples from the IUCPQ’s well established biobank.
  • BioMark will present a proposal for the board of IUCPQ. The outcome of the board decision will be shared later in February 2020 based on a favourable response.
  • BioMark team met with other potential partners in Quebec that will assess opportunity to collaborate on the Pan Canadian Lung Cancer Screening program.
  • BioMark signed a confidentiality agreement with a leading US based genetic test service provider that offers over 4000 genetic based tests to 40 states across USA. Discussions between our mutual scientific teams were held in during the third week of January.
  • BioMark completed drafts related to clinical trial protocols for the upcoming multi centre Chinese Lung Cancer study that will be using an FDA approved drug (rimantadine) as a probe. Meetings were held with a principal scientist leading the project in China prior to the coronavirus global alert. Appropriate milestone payments were received on time as outlined in the agreement between the two parties.
  • BioMark developed synthesized internal standards needed for analysis of urine samples for rimantadine clinical trials in China. The certificate of analysis has also been produced to demonstrate the quality standards necessary for regulatory rigor.
  • New patents for Canada and US have been reviewed and are being filed to protect our new discoveries.
  • BioMark’s certified and accredited lab BRI has completed the development of 12 internal standards that will be used as an assay to assess response to treatment for lung cancer patients following chemo and radio therapy. The result of this proof of concept studies if successful will be another important clinical success for our amantadine and related metabolite panel. The ability to assess faster response will allow for more expedient treatment options for the patients leading to potentially better outcome.



The Quebec Heart and Lung Institute Research Centre is the only centre funded by the Fondsde recherche du Québec – Santé (FRQS) that regroups three research components (cardiology, respirology and obesity-metabolism) deemed to be a priority because of the considerable economic and social impact of their related diseases.


Research with far-reaching effects

The centre’s research themes are central to global health priorities and a major strategic force for halting the progress of non-communicable chronic diseases and their devastating effects. According to the World Health Organization (WHO), non-communicable chronic diseases (cardiovascular diseases, respiratory diseases, diabetes and cancer) are responsible for 63% of deaths worldwide. Obesity, which has reached global epidemic proportions, is one of the greatest risk factors for these diseases.


An integrated research approach

The centre is unique in that our research components perfectly complement the Institute’s clinical missions. This enables health professionals and researchers to work in total synergy to the greatest benefit of patients. This synergy turns research findings into better care in harmony with the vision of the FRQS and of the Canadian Institutes of Health Research (CIHR).Our research teams harness this synergy for the integrated study of the metabolic triggers of cardiovascular and lung diseases, as well as to develop innovative and competitive Quebec research in disease prevention and treatment. In addition, our unique research-care paradigm allows us to identify research priorities according to the clinical issues arising from the Institute’s subspecialties.



MEDTEQ’s mission is, through collaborative, industry led projects, to accelerate innovation and position, on a global scale, products and services developed by the Canadian medical technologies industry, thereby generating major economic impacts while improving healthcare systems for the ultimate benefit of patients in Canada and around the world.  Medteq is a voice in setting health technologies standards, best practices and processes, including privileged access to 180+ member companies, health centres, universities and investors.


MEDTEQ’S Vision 2025

With a dual provincial and federal mandate, MEDTEQ continues to be a focus point for Canada’s medical technology sector in terms of research, innovation and the integration of leading-edge solutions in the delivery of health care.

Press Release – BioMark’s Market Update .doc


Vancouver, British Columbia – (January 21, 2020) – BioMark Diagnostics Inc. (“BioMark”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) and its team of scientific advisors would like to congratulate Dr. John Yoo  for being named Dean of the Schulich School of Medicine & Dentistry on January 6th, 2020.

Dr. Yoo has an international reputation as a pioneering surgeon and an exemplary academic and clinical leader. He currently serves Western as Interim Chair/Chief of the Department of Paediatrics, as Fellowship Director for the Department of Otolaryngology – Head & Neck Surgery, and as a Professor of Otolaryngology and Oncology. Prior to these roles, Dr. Yoo served as Chair/Chief of the Department of Otolaryngology – Head & Neck Surgery for 10 years. As a surgeon, Dr. Yoo pioneered and popularized a technique for reconstructive facial surgery that has been adopted around the world. He has served as Co-Chair of the London Health Sciences Centre’s Facial Nerve Clinic since 2007. Today, in addition to his academic, leadership and clinical roles, Dr. Yoo serves as the Co-chair of Cancer Care Ontario Head and Neck Cancer Disease Site, is the President-elect of the Canadian Association of Head and Neck Surgical Oncology and is an executive board member with the Canadian Association of Otolaryngology and the Asia-Pacific Society of Thyroid Surgery, and he was the longest-serving Chair of the Canadian Chairs of Otolaryngology.

Dr. Yoo will step into his new role as Schulich Medicine & Dentistry’s next Dean on May 1, 2020.

“BioMark would like to take this opportunity to wish Dr. Yoo the very best in his new role. His vision, passion to inspire and guide individuals and institutions is exemplary. BioMark is fortunate to have been supported with his counsel in establishing a rigorous emphasis to focus on end point driven clinical research” says BioMark ‘s CEO and President Rashid Ahmed.


Western University delivers an academic experience second to none. Since 1878, The Western Experience has combined academic excellence with life-long opportunities for intellectual, social and cultural growth in order to better serve our communities. Our research excellence expands knowledge and drives discovery with real-world application. Western attracts individuals with a broad worldview, seeking to study, influence and lead in the international community.


The Schulich School of Medicine & Dentistry at Western University is one of Canada’s preeminent medical and dental schools. Established in 1881, it was one of the founding schools of Western University and is known for being the birthplace of family medicine in Canada. For more than 130 years, the School has demonstrated a commitment to academic excellence and a passion for scientific discovery.


London Health Sciences Centre has been at the forefront of medicine in Canada for 145 years and offers the broadest range of specialized clinical services in Ontario. Building on the traditions of its founding hospitals to provide compassionate care in an academic teaching setting, London Health Sciences Centre is home to Children’s Hospital, University Hospital, Victoria Hospital, the Kidney Care Centre, two family medical centres, and two research institutes – Children’s Health Research Institute and Lawson Health Research Institute. As a leader in medical discovery and health research, London Health Sciences Centre has a history of over 70 international and national firsts and attracts top clinicians and researchers from around the world. As a regional referral centre, London Health Sciences Centre cares for the most medically complex patients including critically injured adults and children in southwestern Ontario and beyond. The hospital’s nearly 15,000 staff, physicians, students and volunteers provide care for more than one million patient visits a year.

Press Release Dr. John Yoo Appointed Dean of Schulich School of Medicine and Dentistry.doc


Vancouver, British Columbia – (December 19th, 2019) – BioMark Diagnostics Inc. (“BioMark”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) is pleased to provide 2019 round up and our outlook for 2020. Below are key highlights.


2019 Round Up


2019 has been a transformative year for BioMark and we anticipate that 2020 would be another pivotal year for the company. Below are key highlights and accomplishments that has set up the stage for an exciting 2020.


Patent Filed

  • The company filed 4 provisional patents from scientific activities. These patents are critical in protection of our discoveries and valuation of our enterprise.


Peer Reviewed Publications

  • We had a blockbuster year. We collectively managed to publish 5 manuscripts and have submitted another 2 in December 2019. 1 article was electronically published for the 2019 American Society for Clinical Oncology (ASCO) meeting while the other was featured in the Cancers Journal in July 2019.


Clinical Trials

  • Trials in both Canada and Bangladesh were completed following the long follow- up studies related to outliers (healthy patients with high levels of Acetyl amantadine). The outcome of the study improved the utility of the Amantadine assay. A submission package has been drafted following a complete review of the study along with all supporting documentation. In addition, relationship with approved medical drug and suppliers have been established. The assay will be used to help physicians zero in on both lung and breast cancers or may later help monitor recurrence for cancer survivors.
  • A mini trial has been completed to assess response to treatment following chemo and therapeutic intervention for lung cancer patients using our SSAT assay platform. The objective is to effectively tailor treatment for patients which would result in lower drug cost and better quality of life for the patients. Results are expected in early part of 2020.
  • A major retrospective study was conducted to discover and validate a panel of plasma metabolites related to early stage lung cancer. Samples were sourced from IUCPQ and the analysis were conducted at TMIC. A total of 260 samples were analyzed with a focus on detecting early stage I and II lung cancer. The results were strong, and a paper has been submitted to a leading journal focused on lung cancer. The company intends to complete a bigger trial based on statistical analysis in 2020. A total sample size of 1200-1500 will be sourced and analyzed next year. BioMark will be applying for a grant to help offset the cost of the trial. This is discussed below under Grants section.


Presentations made at:


  • University of Maryland – Dean and his group at the school of medicine


  • Grand Rounds Medical Faculty Presentations – Drs. Maksymuik and Sitar presented data on early detection/diagnosis of cancer at the University of Medicine Department of Medicine Grand Rounds.


  • Poster presentations abstracts at The Canadian Pharmacology and Therapeutics held in June 2019 Calgary by Dr. Don Miller’s group
  1. Abstract Title: Physiologically based pharmacokinetic modeling of amantadine and acetyl amantadine metabolites for potential applications as cancer biomarker.
  2. Abstract Title: Selective Modulation of SSAT1 Expression for Cancer Cell Sensitization and Therapy.


Global Alliances

BioMark managed to increase its global network and traveled to China, Japan and United States in search of strategic partners in the medical diagnostic and clinical trial arena. The relationships remain dynamic and several of them have visited BioMark to meet with its scientific and technology group. BioMark was recognized recently by Canadian Trade Commissioner Service (TCS) and was featured in the recent special fall edition (December 5th, 2019 edition) dedicated to leading Canadian Life Sciences companies.





  • BioMark secured a major CHRP grant with Dr. Miller and a high impact multi- disciplinary team to collaborate in developing potentially disruptive diagnostic test for glioblastoma. (Gliobalstoma – GBM is a very aggressive form of brain cancer). The grant was for $750,000 and will be used to assess different agents as potential biomarker for glioblastoma. A panel of new markers will be tested to determine the clinical viability of utilizing a vibrant set of metabolites that can improve identification and care for patients with glioblastoma. Collaborative Health Research Projects (CHRP) is a joint initiative between the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Social Sciences and Humanities Research Council of Canada (SSHRC). CHRP grants support focused, interdisciplinary, collaborative research projects involving any field of the natural sciences or engineering and any field of the health sciences. Good progress is being made on this project.


Medteq Impact Program- non-dilutive funding


  • BioMark is applying for $650,000 to support a Pan Canadian application for the development of lung screening assay in Quebec with Dr. Joubert from IUCPQ as a principal investigator. This study is expected to be instrumental since it involves a group of clinicians, assay kit developers, biostatisticians, health technology evaluators, a certified lab for validation and optimization of the kit. BioMark will only need to cover 20% of the cost.


Capital Raise

BioMark was able to raise capital successfully in 2019 despite a challenging CSE market.  Numerous outstanding warrants were exercised into common shares (at 15 cents) as a result of the share price increase over the course of the year.  BioMark also completed a year-end equity closing that was oversubscribed and offering priced over the market price. We had a group of US and Chinese investors in the last round that was closed on December 13th.

US Penetration

Company was registered in the US.

Planned Studies

  • Glioblastoma Multiforme (GBM) -The initial primary area of focus will be to confirm through a proof of concept study the clinical utility of using tumour biomarker(s) developed by BioMark initially in accelerating assessment following glioblastoma multiforme (GBM) resection and correlating it to existing anatomical imaging tests for confirmation. Drs. Graeme Woodworth (Professor, Department of Neurosurgery, Director, Brain Tumor Treatment and Research Center Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine) and Chetan Bettegowda –(Associate Professor of Neurosurgery and Oncology and Director of Meningioma Centre Department of Neurosurgery Johns Hopkins) will be principal investigators (PIs) on this study. The study is expected to commence after ethics approval is granted estimated by Q2 of 2020.
  • Lung Cancer – A second area of focus will be an assay validation of BioMark’s lung cancer liquid biopsy for utilization in early lung cancer screening initiatives and measuring response to treatment. Dr. Christian Rolfo (Professor at the Department of Medicine at the University of Maryland School of Medicine, Director, Thoracic Medical Oncology, and Director, Early Phase Clinical Trials at University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center) will be the PI leading most of the studies (prospective, retrospective and longitudinal) related to lung cancer. In addition, Dr. Rolfo and his team along with his network at Mount Sinai in New York have been working with BioMark in applying for major grants in the US for early lung cancer screening research program.


2020 – Outlook

Expected Objectives: Revenue Generation, Licensing, Commercialization, Focussed Clinical Application and develop deeper Industry Collaboration

  • Health Canada Submission – Anticipate decision from Health Canada for the SSAT1 amantadine assay by Q2/Q3 of 2020.
  • Apply for non-dilutive funding from Medteq and Canadian Research Society. Collectively the funding would be for around $1 million, although there are no assurances the funding will be received
  • Commence and complete the 300-lung patient trial with our Chinese partners at 2 recognized tumour hospitals using credible CRO. All the protocols and standards will be designed on Canadian Health standards. Analyze the results and submit to CFDA for a larger scale trial. BioMark will be compensated a milestone payment after the successful submission to Chinese regulators. BioMark and both its partners (Chinese and Canadian) intend to publish papers and present key findings from the trials if the results are successful.
  • Publications – Target to publish 3 – 4 peer reviewed manuscripts especially following results of the larger trial in Quebec. It is important to keep our science and discovery relevant to the scientific and the biopharma communities.
  • Build stronger base and infrastructure in US – Expand presence, clinical partnerships and research support at existing partner sites. Seek two or more additional institutions to partner with BioMark. Apply for grants and foundation support. Increase market awareness programs to help corporate visibility and attract capital.
  • Establish office and research support in Quebec to expedite the 1500 early cancer lung screening trial. Develop a Lab Developed test (LDT) test that will be optimized and tested at an accredited reference laboratory. Build appropriate standards and leverage lab infrastructure to beta test the assay. Refine the algorithms using AI. This initiative is expected to be completed within 24 months.
  • Seek and continue to develop deeper partnership / relationships with large biopharma for early lung cancer screening program both in Canada and US
  • Commence and complete a focussed glioblastoma (GBM) study in Maryland that can further generate additional revenues for the SSAT amantadine assay. Key indications for GBM would include ideas to optimize the system for gliomas; discriminate or correlate with specific mutations, grading of tumors, differentiate progression from pseudo progression and measuring disease burden /volume. Results from this study are expected to enable the principal researchers to obtain funding from important agencies such as National Institutes of Health (NIH). Furthermore, an orphan status can be granted by FDA should our test demonstrate efficacy over existing diagnostic measurement standards.
  • Capital Raise – Build a better US story where valuations can be more in line with other companies in our space.
  • Bench Strength – Hire staff to help in commercialization, acceleration of clinical trials and business development
  • File patents to protect our major discoveries in key global markets.


Thank you all for your support in 2019. We wish you, your families and friends Happy Holidays.


Forward-Looking Information

This document contains forward-looking statements.  These statements relate to future events or future performance and reflect management’s current expectations and assumptions.  The words “anticipate”, “expect”, “believe”, “may”, “should”, “estimate”, “project”, “outlook”, “forecast” or similar words are used to identify such forward-looking information.  In particular, but without limitation, this document contains forward-looking statements relating to the potential future financial performance and proposed initiatives of BioMark Diagnostics Inc. (BUX).  Such forward-looking statements reflect management’s current beliefs and are based on information currently available to management of BUX. In particular, forward-looking statements relating to the potential future financial performance of BUX are based on: the financial and operating attributes of BUX as at the date hereof, the anticipated operating and financial results of BUX, the views of management and the board of directors of BUX regarding current and anticipated market conditions.  Although we believe that the expectations represented in such forward-looking statements are reasonable, there is no assurance that such expectations will prove to be correct.  By their very nature, forward-looking statements involve inherent risks and uncertainties (both general and specific) and the risk that the expectations represented in such forward-looking statements will not be achieved.  Undue reliance should not be placed on forward-looking statements, as a number of important factors could cause the actual events, performance or results to differ materially from the events, performance and results discussed in the forward-looking statements. These factors include, among other things: changes in laws and regulations affecting BUX and its business operations,  general business conditions and economic conditions in the markets in which BUX competes, the protection of its contractual, proprietary and intellectual property rights,  actual future market conditions being different than anticipated by management and the board of directors of BUX, and actual future operating and financial results of BUX being different than anticipated by management and the board of directors of BUX.  You are cautioned that the foregoing list is not exhaustive.  You are further cautioned that the preparation of financial statements in accordance with IFRS requires management to make certain judgments and estimates that affect the reported amounts of assets, liabilities, revenues and expenses.  These estimates may change, having either a negative or positive effect on net earnings as further information becomes available, and as the economic environment changes.

Additional information on these and other factors is included in other reports filed by BUX with Canadian securities regulators and available at  The forward-looking statements contained in this document are expressly qualified in their entirety by this cautionary statement.  The forward-looking statements contained herein are made as of the date of this document and BUX does not undertake any obligation to publicly update such forward-looking statements to reflect new information, subsequent events or otherwise unless so required by applicable securities laws.

No representation or warranty, expressed or implied, is made as to the accuracy or completeness of the information contained in this presentation.

This document is not a solicitation for the sale of securities of BUX and under no circumstances is to be construed as, a prospectus, offering memorandum, or advertisement or a public offering of securities.  Offers to sell, or the solicitations of offers to buy, any security can only be made through official offering documents that contain important information about risks, fees and expenses.



Vancouver, British Columbia – (December 16th, 2019) – BioMark Diagnostics Inc. (“BioMark” or the “Company”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) is pleased to announce that further to its press release of November 21st, 2019, it has closed the non-brokered private placement for gross proceeds of $669,347.00 wherein BioMark issued 2,231,157 units at a price of $ 0.30 per unit.

Each unit consists of one common share of BioMark and one-half share purchase warrant. One whole share purchase warrant will entitle the holder thereof to purchase one common share of BioMark at $0.45 per share for a period of two years from the closing date of the private placement, subject to an acceleration clause. The Company will pay finders’ fees in accordance with CSE policies of a total of $ 9,600.00 and issue a total of 32,000 finders’ warrants where each Finders’ Warrant entitles the holder to acquire one share a price of $ 0.45 for a period of two years from the closing date of the private placement, subject to an acceleration clause. A debt conversion consisting of 200,000 units in settlement of the indebtedness in aggregate amount of $60,000 to pay for Due to the Related Party.

The proceeds of the private placement will be used for necessary regulatory submission activities, sourcing clinical samples and general working capital. The securities issued under the private placement will be subject to a hold period of four months and one day.

Certain Insiders, Directors and Officers subscribed for a portion of this placement. Participation of the insiders of the Company in the private placement constitutes a related party transaction as defined under Multilateral Instrument 61-101 (Protection of Minority Security Holders in Special Transactions). Because the Company’s shares trade only on the CSE, the issuance of securities is exempt from the formal valuation requirements of Section 5.4 of MI 61-101 pursuant to Subsection 5.5(b) of MI 61-101 and exempt from the minority approval requirements of Section 5.6 of MI 61-101. The Company did not file a material change report 21 day prior to the closing of the private placement as the details of the participation of insiders of the Company had not been confirmed at that time.