BIOMARK SCIENTIFIC ADVISOR DR. DONALD MILLER TO PRESENT AT THE DELAWARE VALLEY DRUG METABOLISM DISCUSSION GROUP

Vancouver, British Columbia – (September 23rd, 2020) – BioMark Diagnostics Inc. (“BioMark”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) is pleased to announce that on September 29, its strategic scientific advisor Dr. Donald Miller is to present on BioMark’s SSAT amantadine assay for the early detection of cancer at the prestigious Delaware Valley Drug Metabolism Discussion Group (DVDMDG).

 

Rashid Ahmed, President and CEO of BioMark, says, “We are pleased to have Dr. Donald Miller present his important work on the SSAT amantadine assay for the early detection of cancer in such an excellent forum with the distinguished Delaware Valley Drug Metabolism Discussion Group. Don’s work on biomarkers and the blood-brain barrier, as relates to cancer, is a crucial part of BioMark’s mission to use biomarkers to diagnose and monitor cancers early. His talk will increase BioMark’s visibility to companies in the Biopharma and diagnostics space and will further support the scientific foundation of BioMark’s technology platform.”

 

The DVDMDG takes place online on September 22 and September 29, Eastern time. Dr. Miller is presenting on September 29 at 2pm. For more information, please refer to the DVDMDG website at: https://www.dvdmdg.org/

 

About Dr. Donald Miller

Dr. Donald Miller is a Professor in the Department of Pharmacology and Therapeutics at the University of Manitoba. He received his B.Sc. in Chemistry from Bethel College (1985), Newton, Kansas, and his Ph.D. in Pharmacology and Toxicology from the University of Kansas (1991). He was a Marion Merrell Dow Postdoctoral Research Fellow in Dr. Ronald Borchardt’s laboratory at the University of Kansas where he studied biological approaches for enhancing drug delivery and drug absorption (1991-1993). Dr. Miller is an internationally recognized expert in drug transporters and blood-brain barrier function, having served on both NIH and CIHR grant and fellowship review panels, as well as reviewer and site visit examiner for Austrian and European Union based program grant initiatives. Dr. Miller’s research program includes examination of blood-brain barrier changes during brain tumor development and identification of methods for increasing the delivery of chemotherapeutic agents to brain tumor; identification and characterization of drug efflux transport proteins in the blood-brain barrier and the molecular mechanisms influencing activity and expression; and the design and development of nanoparticle drug delivery platforms for CNS applications.

 

About the Delaware Valley Drug Metabolism Discussion Group (DVDMDG)

The DVDMDG provides scientists with a forum to discuss current topics in the drug metabolism sciences and includes scientists from most of the major pharmaceutical companies in the Philadelphia area as well as many local universities and laboratories. The continued growth of the organization since its founding in 1975 attests to the relevance and utility of the group.

Press Release – BIOMARK SCIENTIFIC ADVISOR DR. DONALD MILLER TO PRESENT AT THE DELAWARE VALLEY DRUG METABOLISM DISCUSSION GROUP

BIOMARK APPOINTS DR. JEAN-FRANCOIS HAINCE AS STRATEGIC ADVISOR TO GUIDE ITS EXPANSION INTO QUEBEC

Vancouver, British Columbia – (September 16th, 2020) – BioMark Diagnostics Inc. (“BioMark”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) is pleased to announce that it has appointed Dr. Jean-Francois (Jeff) Haince as a strategic advisor to its management team.

Rashid Ahmed, President and CEO, says, “We are delighted to welcome Dr. Haince into our advisory team. Jeff brings a pragmatic perspective to our bench strength along with a thorough understanding of engaging within the vibrant biotech ecosystem in Quebec and North America.  Jeff’s business and product development expertise with diverse medical, scientific, and business experience applied to strategic planning and innovation management in both academia and biotech industry are important for commercialization of BioMark’s disruptive cancer assays.  Jeff possesses a good understanding of the whole value chain and regulatory landscape in the pharmaceutical/healthcare industry and played a vital role in the commercialization of 2 early cancer detection molecular diagnostics.”

 

About Dr. Jean-Francois Haince

Dr. Haince holds a PhD in Cellular and Molecular Biology from the Faculty of Medicine at Université Laval. He cumulates over 15 years of experience in cancer research and authored over 20 peer-reviewed scientific publications. During his term at DiagnoCure from 2007 to 2015, he has been responsible for the development of new molecular diagnostic tests from product design to clinical validation.  Dr. Haince currently manages a multidisciplinary team of experts at SOVAR, providing advice and project management support to development and deployment of technological innovations stemming from cutting-edge research. He also sits on the Research and Innovation Committee at the l’Institut National du Sport du Québec, advising the Institut’s scientific director on all issues related to its scientific and technical activities.

 

Press Release – BIOMARK APPOINTS Dr. JEAN-FRANCOIS HAINCE AS STRATEGIC ADVISOR TO GUIDE ITS EXPANSION INTO QUEBEC

BIOMARK TEAM INVITED FOR FULL APPLICATION FOR SPARKS GRANT COMPETITION

Vancouver, British Columbia – (September 14th, 2020) – BioMark Diagnostics Inc. (“BioMark”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) is pleased to announce that 2 of its most recent abstract submissions for the Novel Technology Application in Cancer Prevention and Early Detection Spark Grants competition have resulted in invitations to submit full applications for funding. This comes after the organizers of the competition, the Canadian Cancer Society/Canadian Institutes of Health Research – Institute of Cancer Research, and Brain Canada Foundation, evaluated the abstracts for their relevance to funding opportunities in the prevention and early detection of cancer.

 

BioMark would like to thank Dr. David Wishart and his TMIC (The Metabolomics Innovation Centre) team for their abstract which focused on the use of a robust panel of biomarkers for potential early lung cancer screening. In addition, Dr. Horacio Bach’s (University of British Columbia) abstract relates to the development of an affordable enzyme-linked immunoassay (ELISA) kit which are commonly used in laboratories for clinical diagnosis. This customized ELISA kit has been developed using highly specific monoclonal antibodies and tested against industry gold standard Liquid-chromatography-tandem-mass-spectrometry (LC-MS/MS) for potential cancer screening application ideally suited for remote settings. “We have been working with both Drs. Wishart and Bach over the years and are delighted to be associated with them and look to support them to submit their full application due by mid October.  We are excited to be part of this competitive application which seeks to support next generation of disruptive technologies in cancer”, says BioMark CEO Rashid Bux.

 

About Sparks Grant

The Canadian Cancer Society (CCS), the Canadian Institutes of Health Research – Institute of Cancer Research (CIHR-ICR), and Brain Canada Foundation (BC or Brain Canada) have committed a total of up to $2.4M over one year to jointly fund Spark Grants focused on Novel Technology Applications in Cancer Prevention and Early Detection.

Background

The intent of the Novel Technology Application in Cancer Prevention and Early Detection program is to “spark” and accelerate new activity in the development and/or application of truly novel approaches to cancer prevention and early detection. To accelerate progress and uptake in cancer prevention and early detection in the short- to medium-term, CCS, CIHR-ICR and BC are launching this funding opportunity to support Spark Grants designed to gather pilot data to drive the application of truly innovative new technologies, or the novel repurposing of existing technologies into the study of cancer prevention and early detection.

 

Spark Grants will support preliminary research to establish proof of principle in novel cancer prevention and early detection approaches. The goal is to fund high risk, high reward studies, that provide sufficient rationale and/or preliminary data to convince reviewers of the novelty and feasibility of the proposed work. Spark Grants are intended to support the development of new partnerships and the exploration of highly novel concepts, involving researchers from any research area, and particularly from non-traditional cancer fields, such as engineering, AI, robotics, physics, nanoscience, statistics, informatics, computer and data sciences, behavioural science, and any other discipline poised to seed the next generation of disruptive technologies in cancer.

Press Release – BIOMARK TEAM INVITED FOR FULL APPLICATION FOR SPARKS GRANT COMPETITION

BIOMARK TEAM SECURES HEALTH CANADA LETTER OF NO OBJECTION FOR ITS GLIOBLASTOMA CLINICAL TRIAL

Vancouver, British Columbia – (August 27th, 2020) – BioMark Diagnostics Inc. (“BioMark”) (CSE: BUX) (FSE: 20B) (OTCMKTS: BMKDF) is pleased to announce that Health Canada has approved its clinical trial application (CTA) and has granted a Letter of No Objection (NOL) for its application entitled ACETYL-AMANTADINE AS A BIOMARKER IN PATIENTS WITH GLIOBLASTOMA.

 

The company would like to thank Dr. Marshall Pitz the principal investigator and is the Section Head of Clinical Research at the Research Institute at CancerCare Manitoba (CCMB) and other co- PIs that include Dr. Donald Miller, Dr. Thomas Klonisch, Dr. Marco Essig, Dr. David Wishart, Dr. Ted Lakowsky and Dr. Anmol Mann for their excellent effort in developing the protocol, submitting it to ethics review board (ERB) and eventually securing the NOL so that BioMark team can commence the trials by October. “Assembling a high impact multi- disciplinary team to collaborate in developing this potentially disruptive diagnostic test that can improve identification and care for patients with glioblastoma is exciting and critically required to positively impact treatment care for patients suffering with Glioblastoma”, says CEO Rashid Bux.

 

About Glioblastoma Multiforme (GBM)

The most common primary brain tumour in adults is glioblastoma (GBM). Originating from transformed neural precursor cells, GBM is a highly aggressive and infiltrative brain tumour.  The death rate of GBM worldwide is approximately 225,000 per year (1).  While GBM has a lower incidence than many other cancers, the prognosis is particularly poor with average survival from time of diagnosis being approximately 14-16 months (2, 3).  Furthermore, compared to other cancers such as breast cancer, which have seen significant advancements in treatment and increased survival, the survival rates for GBM remain similar to those 30 years ago (4).

Monitoring of tumour response is typically through magnetic resonance imaging (MRI) of the brain, conducted every 2-3 months. The poor prognosis associated with GBM is a combination of lack of early detection, incomplete surgical resections of tumour mass and ineffective postsurgical treatment options.  Thus, the ability to detect GBM while the patient is still asymptomatic is likely to create a positive ripple effect with improvements in both the surgical resection and radiation and chemotherapeutic outcomes.  Perhaps an even more profound impact of the proposed study is the potential use as a diagnostic drug biomarker to monitor GBM progression during treatment and early detection of tumour re-occurrence. Thus, a reliable and affordable diagnostic agent that could monitor therapeutic response in GBM patients would allow the clinician and patient to move to new therapies more quickly. The glioblastoma (GBM) market is expected to grow from $662.0m in 2017 to $1.4bn in 2027 across the eight major markets (8MM*) at a compound annual growth rate (CAGR) of 7.5%, according to GlobalData.

References:

  1. Alphandery E. (2018). Glioblastoma treatments: An account of recent industrial developments. Front. Pharmacol. 9:879.
  2. Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, and Villano JL. (2014). Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol. Biomarkers Prev. 23:1985-1996.
  3. Carlsson SK, Brothers SP, and Wahlestedt C. (2014). Emerging treatment strategies for glioblastoma multiforme. EMBO Mol. Med. 6:1359-1370.
  4. Fine HA. (2015). New strategies in glioblastoma: exploiting the new biology. Clin Cancer Res. 21:1984-1988.

Press Release – BIOMARK TEAM SECURES HEALTH CANADA LETTER OF NO OBJECTION FOR ITS GLIOBLASTOMA CLINICAL TRIAL