The Science of Metabolomics
BioMark’s research is based on the science of metabolomics. Our studies are investigating how metabolomics play a pivotal role in the chances of early cancer detection, in order to improve patient outcomes.
Our research consists of screening for the acetylated form of a drug (called Amantadine) given to patients prior to measurement. This is done via LC MS in body fluids.
This acetylation is performed by the enzyme called Spermine/Spermidine N-Acetyl Transferase (SSAT). It has been documented that elevated levels of SSAT are observed in many cancers including lung, breast, prostate, melanoma and GI cancers.
Clinical trials on patients with cancer, as well as healthy subjects, provided proof of principle. In addition, analysis of SSAT mRNA levels in tissue samples allows determination of cancer type.