According to the National Cancer Institute a biomarker is “a biological molecule found in blood, other body fluids or tissues that is a sign of a normal or abnormal process or of a condition or disease” (NCI) such as cancer.
Biomarkers typically differentiate an affected patient from a person without the disease. There is tremendous variety of biomarkers which can include:
A biomarker can also be a collection of alterations such as gene expression, proteomic, and metabolomic signatures.
Biomarkers can be detected in the circulation (whole blood, serum, or plasma) or excretions or secretions (stool, urine, sputum, or nipple discharge) and thus easily assessed non-invasively and serially. Biomarkers can also be tissue-derived and require either biopsy or special imaging for evaluation.
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Biomarkers have many potential applications in oncology including:
5
Jan, 2018
AI early diagnosis could save heart and cancer patients By Pallab GhoshScience correspondent, BBC News 2 January 2018 Original Article: http://www.bbc.com/news/health-42357257 Researchers at an Oxford hospital have developed artificial intelligence (AI) that can diagnose scans for heart disease and lung…
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29
Nov, 2016
A supramolecular indicator displacement assay for acetyl amantadine, a proxy biomarker for spermidine/spermine N1-acetyltransferase (SSAT) activity Introduction Cancer is a leading cause of death worldwide.1 The number of new cancer cases is expected to increase 40% in the next 15 years in Canada due to an aging and growing population.2 Lung cancer is the most commonly diagnosed in this country (excluding nonmelanoma skin cancers) and accounts for 14% of all…
READ MOREFebruary 27, 2018
Vancouver, British Columbia – (February 27th, 2018)–BioMark Diagnostics Inc. (CSE: BUX, FSE: 20B, OTCMKTS: BMKDF) announces the award of a grant from the Natural Sciences and Engineering Research Council of Canada (NSERC) to partner with Donald Miller, Ph.D., Professor, Department of Pharmacology and Therapeutics at the University of Manitoba, to fabricate new nanomaterial and focus on evaluation of these new nanomaterial for knocking down SSAT1 expression in various cells .The up regulation of SSAT enzyme has been clinically demonstrated by BioMark and others to be highly elevated in lung, breast, […]
BioMark has been funded by various government agencies including NRC IRAP, NRC Engage, Genome BC, Government of Manitoba and DFAIT Canada for various projects with active collaboration at University of British Columbia, University of Manitoba, University of Victoria, University of Waterloo, and University of Alberta since 2006. New research applications to Genome Canada and Genome BC Strategic Innovation Program were submitted in 2017 reviewed by peer groups. Now BioMark is collaborating with Bio banks across Canada to expand our metabolomics study.